mcb450-12s07

mcb450-12s07 - Lecture 12 Proteins of the Blood Office...

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Lecture 12 Proteins of the Blood Office Hours Today 1:00-2:30 Noyes 208
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Plasma and Serum Centrifuging whole fresh blood pellets the cells. The supernatant is called plasma. If one lets blood clot first and then spins it, the supernatant is called serum.
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Major Plasma Proteins Albumin Water soluble Maintains osmolality of blood Serves as a carrier of some lipids, e.g., fatty acids Globulins Soluble in dilute salt solutions Antibodies are a sub-class of globulins, the immunoglobulins.
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Lipoproteins Classified on the basis of density. The greater the protein/lipid ratio, the higher the density
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Immunoglobulins Antigen-Antibody reactions: Ag + Ab = Ag-Ab Some human diseases are autoimmune disorders in which the body makes antibodies against its own tissue components. Examples of above are myaesthenia gravis and Crohn’s disease.
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Immunoglobulin G (IgG) Sketch S S S-S S-S Ag Ag Antibodies are bivalent. Two molecules of Ag combine with one Ab. There are many intrachain disulfide bonds not shown here. S S
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Fibrinogen Fibrin
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Clotting Cascade An amplification cascade.
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A Hypothetical Cascade E 1 inact E 1 act E 2 inact E 2 act E 3 inact E 3 act Assuming each enzyme has a turnover number of 1000/sec, one molecule of E 1
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Clot Dissolution Clots (fibrin) are dissolved by the enzyme plasmin. Plasmin is synthesized as a larger, inactive, precursor, plasminogen. The conversion of plasminogen to plasmin and a peptide is carried out by tissue plasminogen activator, tPA.
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Hemoglobin and Myoglobin
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Energy Production in Animals Fuels + O 2 = CO 2 + H 2 0 Fuel consumption is decentralized: Each cell contains its own energy-generating machinery. Transport is an issue: Oxygen must be
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mcb450-12s07 - Lecture 12 Proteins of the Blood Office...

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