mcb450-15s07

mcb450-15s07 - Lecture 15 Glycolysis Office Hours Today...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 15 Glycolysis Office Hours Today (Tuesday, 3/6/07) 1:00 – 2:30 PM, Noyes 208
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Chapter 14 Chapter 14 is not explicitly assigned, BUT You should read the parts of Chapter 14 covered in today’s lecture, and in future lectures, and you are responsible for that material.
Background image of page 2
Metabolism Definition: The sum total of chemical reactions occurring in cells. Major Divisions: Catabolism: Energy yielding (ATP yielding) conversion of fuels to end-products. Anabolism: Energy requiring (ATP requiring) biosynthetic processes
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Study of Metabolic Pathways What is physiological significance? What are overall substrates and products? What is the occurrence or location? In which cellular compartments? What is ATP cost or yield? Is NAD or FAD involved? What are regulatory sites? Is there hormonal control?
Background image of page 4
Study of Metabolic Pathways Are there branch points in the pathway? What is the relationship to other pathways? Are there important features of key enzymes? What important labeling relationships are involved? Follow labeled C atoms. What is the relationship to disease?
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Glucose Transport Glycolysis (sugar-splitting) occurs in the cytosol. Glucose must be transported into the cell from the extracellular fluid: (Glu) out (Glu) in A glucose transporter is involved. Different tissues have different glucose transporters with varying properties. In some tissues, e.g., muscle and fat, this transport requires the hormone insulin.
Background image of page 6
Hexokinase Reaction Glucose + ATP Glucose 6-phosphate + ADP The reaction is irreversible. Hexokinase is an allosteric enzyme inhibited by its product, Glu 6-P. Hexokinase is found in most cells.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hexokinase and Glucokinase The liver has a specialized hexokinase, called glucokinase, suited to the liver’s role as chief feeder of other tissues in the body. The kinetic properties of glucokinase are
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 35

mcb450-15s07 - Lecture 15 Glycolysis Office Hours Today...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online