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mcb450-19as07 - Lecture 19a Gluconeogenesis Glycogen...

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Lecture 19a Gluconeogenesis, Glycogen Metabolism Office Hours, Tuesday, 4/3 1:00-2:30, Noyes 208
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Human Glucose Requirements Amount per day: About 1 mole = 180 g Brain – Has absolute requirement for glucose. The brain uses approximately 75% of the glucose in the blood.
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Gluconeogenesis Definition: De novo synthesis of glucose from (primarily) non-carbohydrate substances.
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Gluconeogenesis Overview Organs responsible for supplying glucose to the blood: Liver 90% Kidney (proximal tubule) 10% NOT muscle
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Gluconeogenesis Substrates Amino acids (most) derived from breakdown of tissue proteins Ala (most abundant AA) Glu Asp Glycerol, resulting from the hydrolysis of triacylglycerols in adipose tissue Lactate, derived from anaerobic glycolysis in muscle and in erythrocytes.
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Gluconeogenesis: Pathway Features Process mostly involves a reversal of the reactions of glycolysis, except for the irreversible steps of glycolysis. A way is found of circumventing the
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mcb450-19as07 - Lecture 19a Gluconeogenesis Glycogen...

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