mcb450-20s07 - Lecture 20 Lipid Metabolism Office Hours...

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Lecture 20 Lipid Metabolism Office Hours Today (4/10/07) 1:00-2:30, Noyes 208
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Stored Metabolic Fuel
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Advantage of Fat as Storage Form Fats are more reduced than carbohydrates, so they give more ATP per carbon atom. On a weight basis, the advantage is even more impressive: Fatty acids lack –OH groups and cannot hydrogen bond to water. Thus fat stores can be compact.
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Dietary Triacylglycerols These are partially hydrolyzed in the intestine, but new TAGs are resynthesized in the epithelial cells lining the small intestine and are complexed with protein to form lipoproteins called chylomicrons. Chylomicrons carry the triacylglycerols to the liver where they may be converted into VLDL. VLDL carries the dietary TAGs to adipocytes.
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Digestion of Triacylglycerols
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Fat Cells b70: Mammary gland, inactive
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TAG Metabolism in Adipocytes
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TAG Hydrolysis Fatty acids are released from the adipocyte and travel through the blood- stream (complexed with albumin) to other tissues to be used as fuel. Glycerol released upon TAG hydrolysis travels to the liver where it can be used as a substrate for gluconeogenesis.
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Fatty Acids as Fuel Complexes of fatty acids and albumin traverse the circulatory system and thus the fatty acids are delivered to other tissues where they can be used as fuels. Combustion of fatty acids to carbon dioxide and water is an aerobic process occurring in the mitochondrion. The first step in fatty acid combustion is a series of cleavage reactions called β oxidation.
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β Oxidation Overview β oxidation occurs in the mitochondrion. The steps in β oxidation are like those between succinate and oxaloacetate in the citric acid cycle. oxidation with FAD to form a double bond adding water across the double bond oxidizing the –OH to a keto group
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Activation and Transport (Cyt) The fatty acid is delivered to the cell where it will serve as a fuel.
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