lecture9F06

lecture9F06 - Lecture 9: Genetics: Complex inherited...

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Complex patterns of inheritance not described by Mendel More on partial dominance dominance depends on analysis; Tay-Sacks disease Multiple alleles ABO blood group locus Epistasis: an allele of one gene can mask an allele of another gene epistasis in mouse coat color, and in other cases Pleiotropy: a single allele may have multiple effects on phenotype. sickle cell allele Polygenic inheritance Environmental effects Readings: Ch. 14, 14.3 to end Lecture 9: Genetics: Complex inherited patterns variation You need to be able to explain the following to yourself and to me (on exams):
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Post-Mendelian studies have revealed that relationships between genotype and phenotype can be complex degrees of dominance multiple alleles epistasis pleiotropy polygenic inheritance environmental effects
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www.florifacts.umn.edu/Trials/Annual %20Beddin. .. Snapdragons Partial dominance basic idea level of analysis Tay-Sacks disease
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Example of incomplete dominance Partial dominance basic idea level of analysis Tay-Sacks disease
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Assessment of dominance depends on the level of analysis! A heterozygote may display a dominant phenotype at the organismal level, but at a biochemical level may show incomplete dominance. Tay-Sachs disease: caused by absence of an enzyme, hexosaminidase A (Hex-A) Homozygous dominant: normal levels of Hex-A, normal development of child Homozygous recessive: no Hex-A, death of
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lecture9F06 - Lecture 9: Genetics: Complex inherited...

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