Atrial Fibrillation_fall 2012

S affects26millionpeople menwomen regardlessofage

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Unformatted text preview: ation (AF) Multiple reentry circuits (wavelets) in atria – Atrial flutter (AFl) Single reentry circuit Atrial and Ventricular Rates Atrial and Ventricular Rates AF – Atrial rate = 400 ­ 600 bpm Many of these impulses are blocked at AV node – Ventricular rate = 120 ­ 180 bpm Very irregular because of random conduction of beats through AV node Atrial and Ventricular Rates Atrial and Ventricular Rates AFl – Atrial rate = 270 ­ 330 bpm – Ventricular rate = 1:1, 2:1, 3:1 Epidemiology Epidemiology Most common arrhythmia in U.S. – Affects ~ 2.6 million people Men > women – Regardless of age Prevalence ↑ with age Overall lifetime risk of developing AF – 1 in 4 Roger VL et al. Circulation. 2011; 123:e18­e209. Lloyd­Jones DM, et al. Circulation. 2004; 110:1042­6. Epidemiology Epidemiology Has been associated with ↑ risk of mortality – Potential mechanisms Stroke Heart failure Proarrhythmia – Due to antiarrhythmic drugs being used to treat AF Etiology Etiology Increased atrial stretch – Hypertension (HTN) – Ischemic heart disease – Valvular disorders (i.e. mitral stenosis, mitral regurgitation) – Heart failure – Pulmonary disease (i.e. COPD, pulmonary embolus) – Obesity Etiology Etiology Increased sympathetic tone – Hyperthyroidism – Alcohol intoxication / withdrawal (“Holiday Heart”) – Sepsis / infection – Surgery Etiology Etiology Electrolyte abnormalities ↓ K...
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This note was uploaded on 06/01/2013 for the course ECON 2301 taught by Professor Lipsh during the Fall '12 term at Broward College.

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