PHRM 514 - Asthma - Fall 2012 (1)

PHRM 514 - Asthma - Fall 2012 (1) - ASTHMA Gina DeSevo...

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ASTHMA Gina DeSevo, Pharm.D. Assistant Professor Department of Pharmacy Practice Jefferson School of Pharmacy Thomas Jefferson University Pathophysiology I (PHRM 514) October 15 and 17, 2012
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Objectives 1. Describe the pathophysiologic events associated with asthma particularly airway inflammation, airway hyperresponsiveness, airway obstruction, and airway remodeling 2. Describe the various cells and mediators involved in the pathophysiology of asthma 3. Identify risk factors for developing asthma 4. Identify factors that trigger asthma 5. List the signs and symptoms of chronic asthma and an asthma exacerbation 6. Explain methods to diagnose asthma and the expected changes in pulmonary function tests
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The word asthma is of Greek origin and means… 1. Breathing 2. Difficulty breathing 3. Panting 4. Gasping 5. Coughing
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Definition of Asthma n Chronic inflammatory disorder of the airways in which many cells and cellular elements play a role: in particular, mast cells, eosinophils, T-lymphocytes, macrophages, neutrophils, and epithelial cells. In susceptible individuals this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing , particularly at night or in the early morning. These episodes are usually associated with widespread, but variable airflow obstruction that is often reversible either spontaneously or with treatment. The inflammation also causes an associated increase in the existing bronchial hyperresponsiveness (BHR) to a variety of stimuli. Reversibility of airflow limitation may be incomplete in some patients with asthma.” Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health, National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. asthgdln.pdf. Published August 28, 2007. Accessed October 16, 2011.
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United States Asthma Epidemiology n Adults with asthma dx as of 2010 ¡ 18.7 million (8.2%) n Children with asthma dx as of 2010 ¡ 7 million (10%) n Totals as of 2009 ¡ 25 million (8%) ¡ 1 in 12 people Fast Stats Asthma. Centers for Disease Control and Prevention. . Updated June 19, 2012. Accessed October 10, 2012. Vital Signs Asthma in the U.S.. Centers for Disease Control and Prevention. Updated May 3, 2011. Accessed October 10, 2012.
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Vital Signs Asthma in the U.S.. Centers for Disease Control and Prevention. Updated May 3, 2011. Accessed October 10, 2012.
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Asthma Surveillance Data. Centers for Disease Control and Prevention. . Updated May 11, 2011. Accessed October 16, 2011.
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United States Asthma Epidemiology n Principally a disease diagnosed in the pediatric population n Most patients diagnosed by age 5 n 30 to 70% of patients improve or become symptom free by adulthood Kelly HW, Sorkness CA. Asthma. In: DiPiro JT, Talbert RL, Yee GC, et al., eds. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:439-448.
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  • Fall '12
  • lipsh
  • chronic asthma, ed. New York, McGraw Hill Medical

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