Genec tesng can be used to characterize which paents

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: cy. •  Some inherited muta=ons are relevant to cancer therapy, but the majority of pharmacogenomic applica=ons to date have involved soma=c muta=ons. Veenstra 20 5 4/22/13 Varia=on in disease pathogens •  Gene=c varia=on in disease pathogens, or infec=ous diseases, can play a role in drug therapy, and it is some=mes considered a pharmacogenomic interac=on. •  Because gene=cally dis=nct strains of pathogens will respond differently to drugs, knowledge of the gene=c strain can be used to tailor drug treatment. •  This type of pharmacogenomic applica=on is currently applied in drug treatment for AIDS and Hepa==s C, among other condi=ons. Example: Heritable pharmacogenomic varia=on •  6- mercaptopurine is a drug used in treatment of childhood acute lymphoblas=c leukemia as an immunosuppressant. •  The enzyme Thiopurine Methyl Transferase (TPMT) metabolizes 6- mercaptopurine •  About 1 of every 300 pa=ents have a varia=on in the TPMT enzyme that makes them “poor metabolizers” for this drug –  Decreased ability to chemically transform the drug –  Too much ac=ve drug can result in serious side effects, including death –  Too liVle can fail to provide the intended drug effect for this poten=ally fatal condi=on. •  Gene=c tes=ng can be used to characterize which pa=ents are likely to be poor metabolizers of the drug, and the dosage can be lowered to a level that maintains the right amount of drug in the body. 21 Example: Acquired pharmacogenomic varia=on 22 Challenges •  Knowledge of the specific gene=c profile of a tumor can be used to guide drug therapy for the individual pa=ent. •  This type of pharmacogenomics is applied with the drug Hercep=n in the treatment of breast cancer. •  About a fourth of breast cancer tumors will produce more than the normal number of the HER2 receptor proteins that control cell growth. •  This “over- expression” makes the tumor grow more rapidly but also be more sensi=ve to the drug Hercep=n. •  Therefore, a posi=ve test for HER2 over- expression is used to iden=f...
View Full Document

Ask a homework question - tutors are online