Genec tesng can be used to characterize which paents

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Unformatted text preview: cy. •  Some inherited muta=ons are relevant to cancer therapy, but the majority of pharmacogenomic applica=ons to date have involved soma=c muta=ons. Veenstra 20 5 4/22/13 Varia=on in disease pathogens •  Gene=c varia=on in disease pathogens, or infec=ous diseases, can play a role in drug therapy, and it is some=mes considered a pharmacogenomic interac=on. •  Because gene=cally dis=nct strains of pathogens will respond differently to drugs, knowledge of the gene=c strain can be used to tailor drug treatment. •  This type of pharmacogenomic applica=on is currently applied in drug treatment for AIDS and Hepa==s C, among other condi=ons. Example: Heritable pharmacogenomic varia=on •  6- mercaptopurine is a drug used in treatment of childhood acute lymphoblas=c leukemia as an immunosuppressant. •  The enzyme Thiopurine Methyl Transferase (TPMT) metabolizes 6- mercaptopurine •  About 1 of every 300 pa=ents have a varia=on in the TPMT enzyme that makes them “poor metabolizers” for this drug –  Decreased ability to chemically transform the drug –  Too much ac=ve drug can result in serious side effects, including death –  Too liVle can fail to provide the intended drug effect for this poten=ally fatal condi=on. •  Gene=c tes=ng can be used to characterize which pa=ents are likely to be poor metabolizers of the drug, and the dosage can be lowered to a level that maintains the right amount of drug in the body. 21 Example: Acquired pharmacogenomic varia=on 22 Challenges •  Knowledge of the specific gene=c profile of a tumor can be used to guide drug therapy for the individual pa=ent. •  This type of pharmacogenomics is applied with the drug Hercep=n in the treatment of breast cancer. •  About a fourth of breast cancer tumors will produce more than the normal number of the HER2 receptor proteins that control cell growth. •  This “over- expression” makes the tumor grow more rapidly but also be more sensi=ve to the drug Hercep=n. •  Therefore, a posi=ve test for HER2 over- expression is used to iden=f...
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This note was uploaded on 06/03/2013 for the course CHEM 162 taught by Professor N. during the Spring '08 term at University of Washington.

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