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Bar10mm aromatization of t androgens per se do not

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Unformatted text preview: hat the brain was ZW on the left and ZZ on the right. (Bar = 1.0 mm.) Aromatization of T •  Androgens per se do not masculinize neural organization •  Masculinization dependent upon conversion of T to E •  SO why are all females (who don’t produce T) not masculinized? 5 4/1/13 Aromatization of T •  α-fetoprotein produced in large quantities by perinatal rats •  Sequesters estrogens, which are then removed through the placenta and metabolized by maternal liver •  Does not bind androgens v. well Diethylstilbestrol •  a synthetic estrogen that was developed to supplement a woman's natural estrogen production. •  5-10 million pregnant women and the children born of these pregnancies were exposed to DES. Diethylstilbestrol health risks •  Cancer: risk of about 1 in 1,000 for clear cell adenocarcinoma •  Infertility: increased risk •  Pregnancy Problems: ectopic pregnancy, miscarriage, and preterm labor and delivery •  Structural Changes in Reproductive Organs: increased incidence 6 4/1/13 Accessory ducts Embryo positioning 7...
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