MCAT Prep Doc.docx - MCAT Prep Doc Biology Biochemistry Apoptosis is the process of programmed cell death that can occur in multicellular organisms The

MCAT Prep Doc.docx - MCAT Prep Doc Biology Biochemistry...

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MCAT Prep Doc Biology / Biochemistry Apoptosis is the process of programmed cell death that can occur in multicellular organisms. The proteins involved in apoptosis are associated with pathways for cell cycle arrest and DNA repair. These processes are mostly regulated through the interplay of various proteins involved in feedback loops including some of the ones shown in Figure 1. Figure 1 : Feedback loops forming a regulatory network affecting apoptosis, cell cycle arrest and DNA repair. (Bioformatics Institute) According to Figure 1, CDK2 activity would most reasonably increase due to all of the following EXCEPT: A. degradation of p21. B. high cyclin G concentrations. C. a mutation in the gene that produces PTEN. D. high p53 concentrations. Explanation Notice the key in the figure which will allow us to follow each arrow that stimulates the next protein and each symbol for negative feedback which means there will be some downregulation (amount/concentration goes down). [Notice a key step in the diagram:

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