2Alecture+8

greasy fat balls of various sizes and shapes 6 12410

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Unformatted text preview: nders are referred to as regions of secondary structure. The likelihood of folding up into one or the other of these is determined by the sequence of R groups (geegaws hanging off the backbone). Biochemists can predict, based on a protein’s sequence, which parts of the protein will form which sorts of secondary structures. The R groups determine tertiary structure CHARGED + POLAR CHARGED - Oxidized AFFECT 2o To S-S Space-filling model “Ribbon” model What do greasy R groups have to do with anything? Greasy R groups are termed “hydrophobic” because they tend to interact with other greasy things (other greasy R groups, membranes) and exclude water and charged or polar R groups. This “hydrophobic effect” is actually caused by the exclusion of fa_y substances by water, to maximize H bonding between water molecules. Hydrophobic R groups oaen congregate at the center of proteins, leaving polar and charged groups on the outside. ? GREASY FAT BALLS of various sizes and shapes 6 1/24/10 Ter>ary (and quaternary) structure is stabilized by a variety of weak interac>ons between R groups Considering how many millions of possible structures could be “folded” from a single protein, it’s pre_y amazing that proteins fold up right pre_y much every >me they’re made. New proteins must have some help doing this because… Most unfolded (= denatured) proteins never fold up cor...
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This note was uploaded on 06/13/2013 for the course BIS 2A taught by Professor Grossberg during the Winter '08 term at UC Davis.

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