2Alecture+8

Each protein has a precise series of amino acids that

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Unformatted text preview: ugh folding of a linear form. How does the polymer form? How does the polymer fold up? How can you predict what a given sequence is going to do? Could you design a protein from scratch? Quite often, the linear forms simply folds itself up into the desired shape. Thus the code for the 3D form (the protein’s tertiary structure) is hidden in the linear form (its primary structure). The subunit -- a generic amino acid H O H N C C O H R amino Individual amino acids are linked together via “pep>de bonds”. Proteins vary in length from a dozen to a few thousand amino acids. Each protein has a precise series of amino acids that make up its primary structure. Link a bunch of amino acids together, and you get a long, flexible chain. carboxylic acid One of 20 possible geegaws 4 1/24/10 R-groups CHARGED + CHARGED - POLAR GREASY FAT BALLS of various sizes and shapes Greasy fat balls Remember ATP ? --- hydrolysis (splitting) of polyphosphate released energy --- polymerization of PO4 by condensation cost energy (It’s expensive to dehydrate with all the water that’s around) Proteins are also formed by condensation and broken down by hydrolysis. This makes it expensive to make a protein (maybe 300 amino acids). But proteins are much more expensive to make than you’d think, if hydration were the only problem ---- wonder why? Protein = a specific polymer of amino acids COO ­ end And popping out of that “backbone” is also a simple repea>ng structure of H’s and O’s (we’re ig...
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