2Alecture+8

These geegaws interact with specic substrates what

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Unformatted text preview: rectly again. Folded “native” protein ? The bottom line generalities-- If the world’s greatest experts were given the sequence of amino acids in an unknown protein….. Could they tell you the 3D structure of the protein, or its function? A 3-D structure is held together by many weak interactions.  Allows spontaneous folding of a 1D (linear)  polymer into a stable 3D conformation.  (it gets progressively more stable as it folds) - Puzzle of the “protein folding rules” + Greasy R-groups predominate inside  -- the core of the sphere Charged R-groups are outside  -- make surface features to do the catalysis Most proteins have multiple subunits -- binding specificity due to specific surface interactions But before we go on, don’t forget… proteins do a LOT of things besides catalysis… • Act as motors • Acts as carriers or pores • Define cell shape (form the cytoskeleton) • Regulate many processes • Determine cell ­cell interac>ons + Not really -- they could say some general things and make some guesses, but X-ray crystallographers still have job security SPONTANEOUS FOLDING generates a solid with - PATTERNS of “gew-gaws”  ON THE SURFACE. These GeeGaws interact with specific substrates. What are the “weak interac>ons” that determine how a protein folds up? A.  B.  C.  D.  E.  F.  Pep>de bonds Ionic bonds Hydrophobic interac>ons Hydrogen bonds Disulfide bonds B, C, and D are correct 7 1/24...
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This note was uploaded on 06/13/2013 for the course BIS 2A taught by Professor Grossberg during the Winter '08 term at UC Davis.

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