Prokaryotic and Eukaryotic Genomes,Fall 07 Tsquare

Prokaryotic and Eukaryotic Genomes,Fall 07 Tsquare - strain...

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Prokaryotic and Eukaryotic Genomics Genome size and organization Mammalian Genomes Genome Evolution
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Solution of the previous lecture problem
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Today we can construct a minimal genome…
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Microbial and Eukaryotic Model Systems. Genomics 0.5 μ m
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How big are they?
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Bacteriophages, also called phages Have the most complex capsids found among viruses 80 × 225 nm 50 nm DNA Head Tail fiber Tail sheath
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General Features of Viral Reproductive Cycles Viruses are obligate intracellular parasites They can reproduce only within a host cell Each virus has a host range A limited number of host cells that it can infect
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Severe acute respiratory syndrome ure 18.11 A, B
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Bacterial cells divide by binary fission Origin of replication Termination of replication
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From Gene to Protein
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Recombination of the DNA from two different bacterial cells Mixture Mutant strain arg - trp +
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Unformatted text preview: strain arg + trp – CONCLUSION Colonies grew Mutant strain arg – trp + No colonies (control) How did it happen? • Three processes bring bacterial DNA from different individuals together – Transformation – Transduction – Conjugation Conjugation and Plasmids igure 18.17 Sex pilus 1 μ m Model for Gene regulation in Prokaryotes: lac operon Eukaryotic Genomes • In eukaryotes, the DNA-protein complex, called chromatin – Is ordered into higher structural levels than the DNA-protein complex in prokaryotes Figure 19.1 Chromatin packing into chromosomes • In Each “bead” is a nucleosome – The basic unit of DNA packing 2 nm 10 nm DNA double helix Histone tails His-tones Histone H1 Eukaryotic genomes are regulated on many levels Further gene regulation…. Conclusions...
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