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lecture 15-2008-genetic disorders

lecture 15-2008-genetic disorders - Genetic Disorders(Ch 8...

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2/15/08 Genetic Disorders (Ch. 8: 123-132) Lecture outline Review dominance Incomplete dominance Codominance Polygenic traits Continuous phenotypes Genetic disorders Types Inheritance patterns testing Types of Dominance Complete dominance Incomplete Dominance Codominance Codominance : example ABO Blood Types Gene that controls ABO type codes for enzyme that dictates structure of a glycolipid on blood cells Two alleles ( IA and IB ) are codominant when paired Third allele ( i ) is recessive to others Incomplete Dominance Mendel’s 3 rd experiment with snapdragons When mixed red and white snapdragons, F1 generation was pink (intermediate) F2 generation has 1:2:1 ratio of homozygous red to heterozygous (pink) to homozygous white Most traits are not coded for by single genes “polygenic” – traits influenced by multiple genes E.g., Skin color, arm length, eye color, etc. Human skin color is codominant and influenced by 3 genes The greater the number of genes and environmental factors that affect a trait, the more continuous the variation in versions of that trait Genetic disorders Inherited conditions that cause mild to severe medical problems Why don’t they disappear?
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