osteoclasts bone destroying cells o break down bone

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Unformatted text preview: tissue secreted • Made of: Collagen fibers embedded in GAGS  Matrix of organic tissue also called osteoid o Calcification: (matrix is hardened via ossification)  Hydroxyapatite crystals are added  The deposition of Ca salts give the bone its hardness • Trapped in lacunae – go from bone synthesizing to bone maintenance cells (after bone done being sytntehsized Osteocytes • Found in mature bones • Maintains bone matrix • Can be recruited to become osteoblasts o Adaptable body!! Osteoclasts • Bone destroying cells o Break down bone • Needed for: o Bone turnover – healing and growth required for e.g. a break or fracture o Mobilizing calcium (and Phosphorous) stores to meet needs (if not getting in diet) o Getting rid of wastes ?? 2 • • Large and motile Derived from stem cells found in bone marrow + spleen Mature Bone: • Contains osteocytes – mature bone cell involved in maintenance activities o Come to existence by osteoblasts being trapped in the lacunae of the mature bone o The process of synthesizing bone traps the osteoblast in the ossified matrix called the lacunae  Lacunae = small cavities (“little lakes”)  Osteoblasts transform themselves into osteocytes (bone cells) o Osteocytes can be converted back to osteoblasts if needed o Communicate to each other and blood through canaliculi (small tubes)  Long cytoplasmic extensions pass through the canaliculi into regions where diffusion takes place • Gas exchange, nutrient and waste Two Main Classes of Bone: Spongy and Compact – major characterist...
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This note was uploaded on 06/29/2013 for the course ANSC 2340 taught by Professor Iramandell during the Winter '12 term at University of Guelph.

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