Lecture 25 - Dhillon

Endocrine gland h h carrier h carrier plasma plasma h

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Unformatted text preview: hormone and there is also protein-bound hormone -There is an equilibrium bet ween hormones bound to a carrier and free hormones What determines the amount of active hormone in the plasma? Endocrine gland H H-carrier H-carrier Plasma Plasma H H H H H-carrier Metabolism in liver, kidney Excretion in Physiological Response urine (depends on free hormone and number of receptors) H Target cell H-carrier H H H H Hormone + Protein <--> Hormone Bound to Protein -If you take away hormone, you're going to shift -----> this way -Similarly, if you take away the hormone bound protein, you will shift <------- that way -There are really small concentrations of hormones in the body (nanomolar) to produce a physiological efect -Metabolism and production will also play on this eqm (if you produce more hormone, it will shift the e quation --> How are hormones detected/measured? Hormones are exceptionally potent chemicals Nanomolar (10-9 M) to picomolar (10-12 M) (Range) Hormone measurements (sensitive method): Immunoassay: tagged antibody specific to hormone (detection in blood and urine) Immunohistochemistry: detection in tissue -Advantage: you know where the hormone is in relation to that cell. Tells us where the hormone is in the body! -Rarely used in medicine. We use it to se BRCA2 hormones (cause breast cancer in women) Both use antibodies that specifically bind to part of the hormone Case Study: Man with hyperglycemia A 51-year-old man visits his doctor complaining of decreased alertness, withdrawal, irritability and sleepiness. He is not obese. Laboratory data: Fasting blood glucose concentration = 9 mmol/l (normal range = 4 - 6 mmol) Plasma insulin concentration = 80 IU/ml (normal range = 5 - 25 µU/mL) Questions 1) What are the possible causes of this disease? Case 2) How would you treat him given each possible cause? Study Next class Hormone receptors and signal transduction...
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