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Lec 38 Evolution and the contemporary world

G crohns disease hoberg et al 2001 6 whipworm

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Unformatted text preview: and 1.71 mya (tapeworms come from meat) Our immune system may “expect” such infections; worms emit substances reducing immune response Lack of exposure to pathogens and parasites in childhood may result in miscalibration of the immune system Autoimmune disorders: immune system attacks body’s own cells (e.g., Crohn’s disease) Hoberg et al., 2001 6 Whipworm infection as a treatment for Crohn’s disease (Summers et al., 2005) •  •  •  •  Crohn’s disease common in industrialised Western countries Uncommon where most people carry worms Helminths diminish immune responsiveness and reduce inTlammation in colitis Exposure to helminths may help prevent or even ameliorate Crohn’s disease (A) Percentage of patients achieving remission or response at week 12 or 24 after initiating ova therapy. (B) Mean change in Crohn’s disease activity index (CDAI, mean (SD)) for respondents to ova therapy. CDAI <150 is remission. p<0.0001, week 12 or week 24 compared with baseline (time 0). 7 Evidence for evolved environment preferences •  Preferences for trees affording refuge, landscapes avoiding line- of- sight (Orians & Heerwagen, 1992) •  Children’s nighttime fears reTlective of where they would take shelter at night (Coss & Goldthwaite, 1995) •  Mental and physical health correlated with window views in prisons, hospitals, and inner- city apartments (Moore, 1981; Ulrich, 1993; Kuo et al 1998) D...
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