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Unformatted text preview: on, interacts with
receptor. activates rapsyn
which leads to clustering of
ach receptors. Agrin binds to receptor and through the pathway shown above causes
c lustering of AchRs. MuSK protein is necessary boht for early
prepatterning of AChRs that is observed in the absence of motor axons,
as well as nerve-induced clustering. muscle has intrinsic ability to induce some clustering on its own. ach receptors being clustered important for maintaining proper muscle? Synapse elimination" First, intrinsic muscle clustering works and then agrin works to further increase the
AChR clustering. Thus, intrinsic properties are the ﬁ rst to work. There is high speciﬁcity in the neuromuscular junction. ONE NEURON ONE MUSCLE FIBER ~ multiple NMJ development: post-synaptic"
Primitive muscle cells" first have a bunch of neurons on one muscle fiber
but then at the end, only one so must have synaps...
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- Spring '12