L. 3a ~ Synapse Formation

Synapse elimination to stabilize mature nmjs know this

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Unformatted text preview: e elimination AChRs appear" then intrinsic clustering agrin Innervation leads to receptor clustering" Loss of extrasynaptic receptors" Subunit exchange" synapses from that neuron da fuck? Synapse elimination to stabilize mature NMJs " KNOW this. motor neurons induce the maturation (loss of extrasynpatic receptors) of t he neurons. End result is 1:1 specifi c connectivity. Development of CNS synapses" CNS Synapses" This is an EM of central synapses. Dark = high electron dense materials. It is much easier to monitor neuromusucular junctions as opposed to specifi c s ynapses. NMJ vs CNS Synapse" NMJ" Primitive muscle cells" AChRs apear" CNS" Developing neuron" CNS receptors appears (e.g. GlycRs)" Innervation leads to receptor clustering" Innervation leads to receptor clustering" Loss of extrasynaptic receptors" Loss of extrasynaptic receptors" Subunit exchange" Synapse elimination to stabilize mature NMJs " Subunit exchange" Synapse disassembly and plasticity " This is the end of developmental neurobio. Will not be tested:)...
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