M5AssgnBrannonS.docx - 1 Running head PARKINSON CASE STUDY...

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1Running head: PARKINSON CASE STUDYWeek Eight Case Analysis: CardiovascularStafford BrannonNURS-6501: Advanced PathophysiologyDr. Gloria BrandburgJanuary 24, 2021
2PARKINSON CASE STUDYPathological Processes Accounting for Presenting SymptomsPrimary Parkinson disease (PD) is a neurodegenerative disorder of the central nervous system that leads to the degeneration of nerves causing autonomic dysfunction as well as both motor and nonmotor and neurologic symptoms. The pathology of PD is not fully understood but is thought to be the result of a loss of dopaminergic pigmented neurons in the substantia nigra (SN) pars compacta, a portion of the midbrain, and dopamine deficiency in the striatum’s putamen portion (McCance and Huether, 2019). Neurological and Musculoskeletal PathophysiologyThe cellular hallmark of PD is seen in the protein misfolding and their aggregation as well as the impairment of protein clearance pathways (Maiti et al., 2017). Intracellular aggregates of α-synucleinin the form of Lewy bodies and Lewy neurites. The formation of Lewybodies in the SN as well as plaque formations similar to Alzheimer’s Disease precedes the patient’s development of neurologic symptoms such as Parkinsonian Dementia (McCance and Huether, 2019). The loss of cholinergic subcortical input into the cortex is also associated with

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