April6 - Many Important Discoveries about Cell Cycle...

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Chapter 17 Read Pages 983-996 The Cell Cycle
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The Cell Cycle is an Ordered Series of Events Leading to the Replication of Cells Figure 21-1 Molecular Cell Biology (Fifth Edition) Lodish, et.al.
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Mitosis is the Most Easily Recognized Part of the Cell CycleTypically Lasting ~1hr. Figure 20-29 Molecular Cell Biology (Fifth Edition) Lodish, et.al. Read Page 985
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Just the FACS please…… use BrdU to label DNA Cells with more fluorescence have more DNA (ie they have undergone replication) G1 S G2
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Diverse experimental systems have been used to identify  and isolate cell-cycle control proteins Cultured cells  Xenopus laevis Because of its availability in large numbers,size and unique development, Xenopus oocytes  and embryos has been the system of choice for the critical biochemical characterization of cell  cycle components.       Sea Urchins also very popular in this regard The budding yeast Saccharomyces cerevisiae The fission yeast Schizosaccharomyces pombe
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Unformatted text preview: Many Important Discoveries about Cell Cycle Control have Come from Studying Yeast Reproduce rapidly Have small genomes Amenable to rapid molecular genetic manipulation Proliferate in a haploid state The Behavior of a Temperature-Sensitive Cdc Mutant Isolation of Wild-Type Cell-Division Cycle (CDC) Genes from S . cerevisiae Carrying Temperature-Sensitive Mutations in these Genes Figure 21-4 Molecular Cell Biology (Fifth Edition) Lodish, et.al. Cell Cycle Control is often Analyzed Biochemically in Xenopus The Cell Cycle can be Arrested at Specific Checkpoints Cyclins and Cyclin-Dependent Kinases Regulate the Cell Cycle Structural Basis of Cdk Activation Phosphorylation Regulates Cdk Activity Binding of Inhibitory Proteins to the Cyclin-Cdk Complex Renders Cdk Inactive Control of Proteolysis by SCF Anaphase-Promoting Complex (APC) is Responsible for the Ubiquitylation and Proteolysis of M-Cyclins...
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April6 - Many Important Discoveries about Cell Cycle...

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