Cell Junction Notes

Cell Junction Notes - Notes for lecture CELL JUNCTIONS In multi-cellular organisms all cells have junctions(a priori and they usually occurs either

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Notes for 3/23/07 lecture: CELL JUNCTIONS In multi-cellular organisms all cells have junctions (a priori) and they usually occurs either with: Other cells Extracellular matrix (a network of secreted macromolecular complexes) Overall Organization: Tissues (cooperative assembly of cells) Organs (functional units) combinations of tissues Eg: in connective tissue much more extracellular matrix than cells (stress is on matrix) In epithelial tissues cells are tightly bound in sheets with very little matrix (apart from the basal lamina upon which the sheet lies) in between The stress is based on cells Three functional groups of cell junctions Occluding (tight) junctions that seal cells together Anchoring (Adherens) junctions, mechanically ATTACH cells to neighboring cells or to matrix Communicating junctions mediate the passage of chemical or electrical signals from one interacting cell to its partner Occluding Junctions All epithelia serve as a selective permeability barrier, separating fluids on either side that have different chemical composition. This function requires that the adjacent cells be sealed together by occluding junctions. Tight Junctions
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This note was uploaded on 04/07/2008 for the course BSCI 201 taught by Professor Graham during the Spring '07 term at Vanderbilt.

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Cell Junction Notes - Notes for lecture CELL JUNCTIONS In multi-cellular organisms all cells have junctions(a priori and they usually occurs either

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