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bio articles - Lauren Gonter Biology Articles Two Genes Are...

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Lauren Gonter Biology Articles Two Genes Are Key to Regulating the Immune Response Scientists have discovered two genes that are key factors in the body’s immune response. Their discovery fills in an important "missing link" in a biochemical pathway that's long been tied to disorders ranging from lupus and Type 1 diabetes, to cancer and AIDS.” 1 The immune system is “a collection of mechanisms within an organism that protects against disease by identifying and killing pathogens and tumor cells.” 2 All of these parts act together to create the immune response. IL-10 is a protein receptor involved in this process. IL-10 represses T cell activity, to keep from starting too large of an immune response. This is especially helpful when macrophages trigger the IL-10 when there are not enough dead cells around to undergo apoptosis. Apoptosis is when cells naturally undergo death, but sometimes too many good cells can be killed, thus the IL-10 is needed for regulation. The amount of it needs to be kept in balance, because too much of it makes the body susceptible to viruses and cancer. Scientists need to better understand this receptor, in order to better understand these diseases. The genes, pre-B transcription factor 1(Pbx-1) and Pbx-regulating protein 1, are important in hematopoeisis, the production of new and myriad blood cell types, so scientists are
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bio articles - Lauren Gonter Biology Articles Two Genes Are...

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