Inv 2 - PopGen FishBowl Virtual Lab.pdf - Examining the...

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Examining the Conditions of Hardy-Weinberg Equilibrium using the model “PopGen Fishbowl” Introduction Population genetics is the study of changes in allele and genotype frequencies within populations, and of the processes that cause such changes. Applications of population genetics include: Predicting a population’s evolution. For example, a mutation of CCR5 gene in humans seems to confer substantial resistance to HIV infection. We can use population genetics to explore how this gene might evolve in response to the AIDS epidemic and to determine whether this process will bring the epidemic under natural control. Testing specific evolutionary hypotheses. For example, many human genetic disorders such as Tay-Sachs disease, cystic fibrosis, and sickle-cell anemia are thought to be adaptive responses to past epidemics in the affected populations’ histories. Based on measured levels of disease resistance conferred by these alleles, and on the known time and severity of specific epidemics, we may be able to eliminate certain hypotheses while supporting others. Informing debates about public policy. For example, during the first half of the 20 th century, proponents of eugenics advocated compulsory sterilization of people with undesirable genetic traits. Using population genetics, we can explore the effectiveness of such a policy, determine what proportion of the population would be affected, and predict any potential secondary consequences. In population genetics, evolutionary forces are defined as processes that cause allele frequencies to change. The Hardy-Weinberg equilibrium principle describes a population that is not evolving. As such, the allele frequencies are in equilibrium if five particular conditions are met. In this activity, we will use a virtual model of koi (fish) in a pond to understand how different forces can cause allele frequencies to change over time. Procedure 1. Go to virtualbiologylab.org and select Evolution Models, then Population Genetics. Finally, launch Model 1: PopGen Fish Pond. 2. Review the Background Information and answer the questions; please put your answers in a different color for credit: a. What is the difference between microevolution and macroevolution?

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