Cognitive Neuroscience paper - Entorhinal Cortex and...

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Entorhinal Cortex and Semantic Memory Recollection Introduction The entorhinal cortex is a critical memory center in the brain. It serves as an input for both parahippocampal cortex and perirhinal cortex. These structures play large roles in recollection and familiarity aspects of memory (Diana, Yonelinas and Raganath 2007) .The Entorhinal cortex is also the major input and output from the hippocampus to the neocortex, this implies that it plays a large role in various mnemonic processes within the brain (Hafting, Fyhn, Molding, Moser, Moser 2005). Within the rodent brain, it has been found that the neonatal destruction of the entorhinal cortex has caused a degradation in the ability of allocentric learning and thus the ability of maze navigation. The rodents within the experiment that had entorhinal cortex destruction were unable to hold information after delays (Harich, Kinfe and Koch 2008). This sensory input was further studied to show that the Entorhinal cortex plays a role in the localization of space in the brain. This in turn relates to the formulation of semantic memory (Jeffrey 2007). One consideration of particular interest is the functionality of the entorhinal cortex in combination with the hippocampus. A particularly engaging question, is how do these two interact in the formation of long term memory? Through previous research, it has been shown fairly clearly that long term consolidated memory is stored in the lateral neocortex, and it is the entorhinal cortex that connects the hippocampus to the lateral neocortex. It has been suggested the entorhinal cortex is important in the formation of semantic memories (Vargha-Khadem, Isaacs and Mishkin 1993). This hypothesis provides some insight into both the transference of information from the hippocampus to the lateral neocortex but also an idea of what the parahippocampal gyrus and perirhinal gyrus do not do. A study of this functionality would be a critical validation of both the functionality of the entorhinal cortex and an examination of the process of long term memory consolidation. Statement of Research Question and Hypothesis: It has been suggested that the entorhinal cortex plays a variety of roles in cognitive processes. However there is still significant speculation as to how large of a role it plays in the structure and formation of semantic memories. This explicit knowledge is critical towards development and the study of the entorhinal cortex as a major structure in the cognitive process. It is also critical towards the understanding of memory structure and information
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This note was uploaded on 04/07/2008 for the course PSYCH 3903 taught by Professor Repovs during the Spring '08 term at Washington University in St. Louis.

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Cognitive Neuroscience paper - Entorhinal Cortex and...

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