6_glycolysis_pt1

6_glycolysis_pt1 - Glycolysis Overview Steps I-V Lehninger...

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Glycolysis: Overview & Steps I-V Lehninger Chapter 14 Sec±on 14.1
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Glucose: Required for Life Major pathways of glucose utilization E. Coli can obtain from glucose the carbon skeleton for every metabolite needed (e.g. amino acids, nucleic acids, coenzymes, lipids, etc.)
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Three possible catabolic fates of the pyruvate formed in glycolysis
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Glucose: Rich Energy Source Burning glucose C 6 H 12 O 6 ’+’6O 2’ ’6CO 2 ’+’6H 2 O’ ’’ Δ G ´°’=’-2840’kJ/ mol’
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Glycolysis (Sugar Splitting): Capturing Energy From Glucose Spli9ng glucose – small energy loss C 6 H 12 O 6 ’+’2NAD + ’+’2ADP’+’2Pi’ ’2C 3 H 3 O 3 ’+’2NADH’+’2ATP’+’2H + ’+’H 2 O’ Δ G ´°’=’-85’kJ/ mol’ Available for work ’ 2’ATP:’ Δ G ´°’=’-61’kJ/ mol Δ G ’≈’-104’kJ/ mol’ in’erythrocytes’ ’ ’ ’’’’’’’ ( what does this mean? – see Ex. 13.2) (what is Δ G for 2 ATP in E.’coli ?) If aerobic 2 NADH: Δ G ´°’=’-152’kJ/ mol’ 2 pyruvate: Δ G ´°’=’-762’kJ/ mol’
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Glycolysis Reaction Summary C 6 H 12 O 6 ’+’2NAD + ’+’2ADP’+’2Pi’ ’ 2C 3 H 3 O 3 ’+’2NADH’+’2ATP’+’2H + ’+’H 2 O’ Δ G ´°’=’-85’kJ/mol’ 10’steps’ First’5:’invest’2’ATP’&’split’6-membered’ring’in’half’ Second’5:’collect’4’ATP’&’2’NADH’ Final’product’needs’to’be’pyruvate,’for’input’into’the’citric’ acid’cycle’
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Steps in glycolysis
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What ` s in a name? Enzymes’and’pathways’discovered’ via ’funcZon’are’generally’ named’for’those’funcZons’ Glycolysis:’ sugar lysis Hexokinase:’ hexose phosphotransferase (from ATP)
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I. Hexokinase Large’ligand-induced’conformaZonal’change’ Four’isoforms’in’human,’I-IV’ Highly’regulated’(coming’in’ Chpt.’15)’
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6_glycolysis_pt1 - Glycolysis Overview Steps I-V Lehninger...

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