Amino_Acid_Synthesis_Figures

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Unformatted text preview: bout every amino acid requires transfer of amino group from glutamate or amide group from glutamine. Synthesis of aroma@c amino acids in plants requires chorismate, a product of the shikimate pathway. The ac@ve ingredient of the herbicide Round ­up is glycine phosphate, or glyphosate, is a transi@on state analogue occupying the phosphoenolpyruvate binding site of 5 ­enolpyruvylshikimate 3 ­phosphate synthase. Glycine and succinyl ­CoA are required for synthesis of heme. The point of this slide is to demonstrate the importance of amino acids in the synthesis of many biologically important molecules. No need to memorize the pathway. Muta@ons in the porphyrin synthesis pathway lead to porphyria, diseases characterized by neurological dysfunc@on and intense abdominal pain. Biliverdin, the breakdown product of heme catalyzed by heme oxygenase, is a powerful an@ ­ oxidant. Bilibrubin is also a strong an@ ­oxidant. Urobilin is the source of the yellow color in urine. Phosphocrea@ne, the short ­term reserve of high ­energy phosphate compounds, is derived from three different amino acids. Amino acids are precursors of many signaling molecules. Examples include neurotransmigers, adrenal hormones norepinephrine and epinephrine, and nitric oxide....
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This note was uploaded on 09/19/2013 for the course BIOC 462b taught by Professor Grimes,tsao,borque during the Spring '08 term at University of Arizona- Tucson.

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