Acid concentration in blood under fasted conditions

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Unformatted text preview: (B) (1 pt) The transformation depicted in part A is catalyzed by: (A) (B) (C) (D) Pyruvate carboxylase Glutamate dehydrogenase Ribonucleotide reductase Nitrogenase complex Page 5 of 5 Answer: ______ Name: _______________________________________ Net ID: ______________________ (C) (3 pt) N2 NH3 (D) (1 pt) The transformation depicted in part C is catalyzed by: (A) (B) (C) (D) Pyruvate carboxylase Glutamate dehydrogenase Ribonucleotide reductase Nitrogenase complex Answer: ______ Question 13. (3 pts) Which of the following chemical structures is common to both methymalonyl- CoA mutase and ribonucleotide reductase reactions? Methymalonyl- CoA mutase utilizes coenzyme B12 as co- factor and is required for metabolism odd chain fatty acids by converting methylmalonyl- CoA to succinyl- CoA. (A) Acyl phosphate (B) Schiff base (C) Radical (D) Biotin (E) Enediol Answer: ______ Question 14. (7 pts) Methotrexate, a chemotherapeutic agent against cancer, is a structural analogue of folate. It is a potent inhibitor of dihydrofolate reductase. Page 6 of 6 Name: _______________________________________ Net ID: ______________________ (A) (2 pts) Defects in which of the following pathways will likely result from methotrexate treatment? (A) Glycolysis (B) DNA synthesis (C) RNA synthesis (D) Pentose phosphate pathway Answer: ______ (B) (5 pts) In addition to the pathway in part A (and independent of it), methotrexate treatment has a serious side effect that is also found in folic acid deficiency. Folic acid deficiency is believed to be the most common vitamin deficiency, and it causes a type of anemia in which hemoglobin synthesis is impaired. In this type of anemia, there is NO deficiency of vitamin B12. Consult the figures on folate metabolism and dTMP synthesis, provide an explanation for why folate deficiency impairs the synthesis of the porphyrin rings in heme. The answer to part B does not involve the answer in part A. Question 15. (15 pts) This question concerns pathway integration. (A) (12 pts) Label each of the following pathways as does occur or does not occur in your body. (i) Formation of glucose from amino acids Answer: _______________ (ii) Formation of ketone bodies from fatty acids Answer...
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This note was uploaded on 09/19/2013 for the course BIOC 462b taught by Professor Grimes,tsao,borque during the Spring '08 term at Arizona.

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