Lecture 18 Introduction to Metabolism-BW

Action promotes glucose uptake liver is the organ of

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Unformatted text preview: gan of metabolic regulations help control waht the rest of the body does based off the nutrients - not dependent on trasnporter - liver already has trasnporter there Liver take up a lot of glucose from meal and put it into storage - all of these tissues involved in biosytheiss 3/27/13 MCB 2000 Lecture 18 Insulin promotes transport of glucose into cells biosynthesis of glycogen , triglycerides, protein Glucagon Small proteins -receptors at the cell surface G lucagon - catabolic breakdown - it is released in r eponse to lower blood glucose . Small protein made in the alpha cells of the pancreas Signals that the current supply of glucose is inadequate to meet the fuel requirements of the body. Glucagon is a catabolic hormone--it promotes breakdown of larger molecules (energy stores: glycogen & fat) to provide energy/fuel when it is not coming from the diet. 3/27/13 MCB 2000 Lecture 18 Response to Glucagon Signal transduction is the same as epinephrine in liver 3/27/13 MCB 2000 Lecture 18 Major Sites of Glucagon in adipose tissue trigger glucagon to breakdown someone of the fat and does the same in liver. main storgage of trylogide in the adipose tissue 3/27/13 MCB 2000 Lecture 18 Muslce store a lot of glucagon - no receptor for it - no receptor not going to response for the hormone - even though muscle has a lot of glucoagn it will not response to glucagon becuase there are no reeptors to trigger that events Why is there no effect of glucagon on muscle? How do insulin and glucagon maintain glucose homeostasis? insulin / glucagon Stimulates transport of glucose into skeletal muscle and adipose tissue Stimulates synthesis of glycogen from glucose Glucose levels in blood return to normal following a mixed meal. insulin / glucagon Promotes breakdown of liver glycogen and release of glucose into blood. Promotes gluconeogenesis (synthesis of glucose) in liver 3/27/13 MCB 2000 Lecture 18 Metabolism Describes the chemical & energy transformations that all cells and tissues perform as an essential part of life. Major energy currency - ATP. ATP is the highest concentration of all the nucoletides that you want in the cell Reactions in metabolism - use GTP ( protein sythesis uses GDP) activatino of TRNA - use ATP. for example phosphlipids biosythesis - uses CTP some reactions perfer certain nuceoltides. Not the only functino of ATP - also allosteric inhibitor. also r egulator - regulate invovled in producting it - TCA cycle glycosis r egulated by ATP - repeatting patterns ( ATP as a regulatory) contstant cycle of ATP sythesis and break down - take nutrients in the diet in presence of oxygen - broken down (catabolsim) oxidavtive pathway it also release energy (exergonic) - oxidation of nutrients releases energy - considered a c atabolic pathway - end products CO2 and water 3/27/13 Synthesis - building molescules anabolsim - aganist entropy - covalent bonds - input of energy - click to link s omething together need enregy - fatty acid, cholesterol - all g...
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This note was uploaded on 09/17/2013 for the course MCB 2610 / 200 taught by Professor Feldman during the Fall '12 term at UConn.

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