Lecture 18 Introduction to Metabolism-BW

Basal metabolic rate your kidney lration and breathing

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Unformatted text preview: our kidney fi lration and breathing (any automoic system) - keep your body going - at rest. (BMR measured at rest) - small % is going to be used to maintain body temp s urprisingly is that when you consume food - the digestive process excends energ - consume a moderate breakfast becuase it not only gets your metbaolic going and its burning some calories . when y ou eat protein you burn more calories digesting then c arbohydrates. stay fuller when you consume protein - most of your calories. more muslce higher BMR - can consume more calories - your BMR will be dictacted by thyroide hormone - body composition how many calories you can consume . (BMR) 3/27/13 MCB 2000 Lecture 18 Importance of maintaining blood glucose Daily need for glucose Brain needs ~120 grams Body fluids 20 grams Glycogen stores ~4.5 mM 160 grams 190 grams Why is blood gluocse important? - Normal blood glucose = 100 ml per CC of blood a little bit lower is ok - your body on average needs 160 grams of the 160 grams you brain need 120 - the size of you brain and what it weights relative to skeltal muslce the brain has a disporptional for blood glucose - that is why that it cruical to maintin glucose homeonstatis- normal blood glucose is about 80 - go to around 40 - can go into a coma - brain not getting enough gluocse to a brain (hypogluocis) - the shakes. s tore away gluogan - sotrgea 190 grams - maintin you for with 24 hours without eating - the brain is so dependent on glucose becuase it cannot use fat for energy when everyone other tissue in the body can - your body is going to start tapping into fat s toarge but the brain cant do this - 3/27/13 MCB 2000 Lecture 18 How is blood glucose regulated? within about 4 hours your blood glucose levels return to about 100 - within the 4 hour window (body is r estored to 100 glucose level) - as glucose level rise it spikes as soon as your eat a carbohydrate c ontainging meal - insulin is r eleased where as gluoagon levels are not dramatically effected Glucose itself Importance of 2 hormones Insulin Glucagon Both insulin and glucagon alter the activity of enzymes by changes in phosphorylation/dephosphorylation (respective signal transduction cascades) http://highered.mcgrawhill.com/sites/0072495855/student_view0/chapter20/animation__blood_s ugar_regulation_in_diabetics.html 3/27/13 Insulin Insulin- metbaolic anabolic homrone - promotes sythesis of fatty acids phosplipids cholrestoral - all of your body needs - your body doenst produce insulin (type I diabetes) type II body produces insulin but doesn't r esponse to the inusiln singalling casade Small protein made in the beta cells of the pancreas. Released into the blood in response to elevated blood glucose Insulin is an anabolic hormone--it promotes the synthesis of larger molecules from smaller building blocks Failure to produce insulin or failure to respond to insulin results in Diabetes. 3/27/13 MCB 2000 Lecture 18 Major Sites of Insulin Action Promotes glucose uptake - liver - is the or...
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