Lecture 18 Introduction to Metabolism-BW

Link s omething together need enregy fatty acid

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Unformatted text preview: oing requrie the input of enregy - small molecules to Breakdown large molecule - whenver ATP make ( catabolism) - then used to build up moelcules - Anabolsim - reductive building up - the reaction invovled are oxidation (break dwon) reduction ( building a molecule) whenever carry out oxidation going to invovle a reduction - happen in pairs Synthesis MCB 2000 Lecture 18 F i g. 15-9, p.426 Metabolism Objectives: Metabolism involves redistribution of energy between compounds: ATPADP cycle What do we need ATP for - active trasnport requries energy - require energy becaues going aganist a concentration gradient - lower to higher- aganist entropy - normally passive, and faciliated diffusion all go with the concentration gradient (high to low) sodim potassium ( potassium higher in the cell) - consumes about 1/3 of all ATP that is made in the cell - one trasnport - maintaining the gradient. -whenver phospholate a protein - consuming the ATP. to make the ATp need to oxidize soemthign 3/27/13 MCB 2000 Lecture 18 What makes ATP particularly efficient energy currency? High Phosphoryl Transfer Potential of ATP Electrostatic repulsion Resonance stabilization Stabilization due to hydration Why is ATP the important energy currency in the cell? - If look at the strucutre of ATP 3 phosphate in a row - it is within the phospho and an. bonds - high energy bonds therefore ATP is a molecule that high phosphortrasnfer - its willing to give up its phsophate . phsopahte exsist as reasonacne sturcutre - ATP hydrated molecule - 3 factors that ATP is willing to give up its phosphate 3/27/13 MCB 2000 Lecture 18 Other molecules with high phosphoryl transfer potential ATP not the only moelcule with a higher phsophoyrl potential. glyosis - put in energy to make ATP - make ATP is glyosis it not dependent on oxygen (anaerobically) . donate there phosphate to ADP . when phsophate released - liberate more than enough energy to sythesis ATP - its able 30 kj/mol - these two molecules have more enrgy an ATP and used in glysosis to phsophlyate ADP to ATP - the other molecule used by muslce is creatine phosphate - used when your invovled in high intensisty short workout 3/27/13 MCB 2000 Lecture 18 build up ernegy - give up phosphate and ATP can be s ythesiszed ATP is able mid way down the table can provide enrgy to sythesis aTP under anerboic c onditoins . Central Position of ATP in Phosphoryl-Transfer Reactions wiling to get up there phsophate and can be used to sytehsis other moelcules - glucose and glycerol - lower than ATP to phosporlyate glucose - ATP going to be c onsumed - not theremodynamlically favored needs to be coupled 3/27/13 MCB 2000 Lecture 18 ATP Synthesis & Consumption Fuel oxidation glyolcysis = NET 2 ATP. most of ATP comes from aerboic respiration - consuming fat carb and proteins - gibes adicticoade - oxidated in the cycle and loss 8 electrons - those elctrons c aptured by NAD+ and when it accepts it becomes NADH- fully oxidiize - capture the electrons - the elctr...
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This note was uploaded on 09/17/2013 for the course MCB 2610 / 200 taught by Professor Feldman during the Fall '12 term at UConn.

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