Lecture 26 Glycogen Synthesis-BW

Out the activaiton step not a one time only stpe

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Unformatted text preview: glucose - the strucutre of glycogen - a lot of gluocse molecule every one needs the consumption of UTP. Glycogen synthesis requires a primer made by Glycogenin G Lycogenin - enzyme that makes the primer for glycogen synthesis when you syntehzse DNA - require - RNA primer. need a primer made by glycogeinin - short (gluocse. glycognin makes the primer k nown as gluocse. 4/15/13 MCB 2000 Lecture 26 glucose 1-phsophate - UTP molecule when you make UTP glucose - not spilting the gamma phsophate - we are transfering the alpha phosphate and the uridine. -normal spilt off the gamma phosphate - this case you are spilting at the beta phosphate - left with the alpha phospahte with urinde. Activation of glucose for glycogen synthesis enter a bond with glucose 6 phosphate. uppercase PPi. pyruophosphate - carry out the activiation step - liberate pyruphosphate - will be cleaved into two inorganic pphosphate - a lot of enregy relaed. the driving force for linking with glucose 6 phosphate - provied by hydroyzle of pryophosphate. becuase spillting the beta and gamma phsophate - equail in terms of energy. Gamma phosphate using molecule of 2 molesulces of ATP - to activat the movement. T h e h igh e n e r gy p hosp h a t e bon d f r om U T P p r ov i d es t h e e n e r gy fo r t h e fo r m a t ion of t h e h igh e n e r gy bon d i n U D Pgl u cose . T h e l i b e r a t ion of p y r op hosp h a t e ( P P i) a n d i ts h y d r ol ysi s (e q u i v a l e n t t o 2 A T P 2 A D P ) d r i v es t h e r e a c t i o n . 4/15/13 MCB 2000 Lecture 26 Synthesis of Primer by Glycogenin G l y coge n i n c a t a l y z es t h e a d d i t ion of t h e f i r st 6-8 gl u cose r esi d u es (p r i m e r ), a f t e r w h i c h G l y coge n Sy n t h ase t a k es ov e r . P r i m e r c a n b e sy n t h esi z e d de novo. to make primer have to go through thte acitivation step - once you make the primer then glyocginin synthezie c an happen. 4/15/13 MCB 2000 Lecture 26 Glycogen synthesis: Glycogen Synthase Primer Primer made by glycogin - required activation stepadd one glucose reside until reach a point. where/ G l y coge n sy n t h ase is t h e m a j o r e n z y m e i n vol v e d i n e x t e n d i ng t h e p r i m e r. G l y coge n p r i m e r r e m a i ns a t t a c h e d to gl y coge n i n . E a c h gl u cose t h a t is a d d e d m us t b e a c t i v a t e d w i t h U T P. 4/15/13 MCB 2000 Lecture 26 \where you have c ore - then glyocgen s ynthase can go on to add 1 glucose r esidue at a time to the exsising core - to make the branched part (about 11 r eisdue) - once you get to a certain length the branching enzyme will cleave off and create alpha 1,6 linkage Glycogen synthesis: extending the chain 4/15/13 L i n e a r c h a i n l e ngt h i n c r e ases to ~11 r esi d u es w i t h G l y coge n sy n t h ase G l u cosy l r esi d u es a d d e d f r om U D Pgl u cose to non r e d u c i ng e n ds of c h a i n b y -1 , 4 l i n k a ges. MCB 2000 Lecture 26 C l e a v a g e o f 6- 8 r esi d u es b y...
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