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Unformatted text preview: Hemoglobin has 4 hemes, each heme may carry 1 CO2 Negative feedback homeostasis Regulates the oxygen content of the blood Low blood oxygen Kidney releases EPO EPO stimulates bone marrow to speed RBC mitosis & developme nt If kidney fails, body suffers severe anemia Breakdown of RBCs Occurs in marcophage that can be found in the liver, spleen, or bone marrow iro n heme Transport ed in circulation to form new RBC Gets transferred into biliverdin Biliverdin --> bilirubin Primary removal: liver to bile (bilirubin excreted in bile) Primary removal: liver to bile (bilirubin excreted in bile) Jaundice: Excessive amounts of bilirubin in blood causes yellowing of eyes & skin Liver damage & sickle cell anemia Viscosity exponentia lly increases as % of RBCs increases 2 types of blood doping Increase RBCs by injecting EPO or blood transfusion Affects blood flow & increases rick for <3 attack...
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- Fall '08