Adenoviruses - Adenoviruses What are Adenoviruses...

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Adenoviruses What are Adenoviruses? Non-enveloped viruses with double-stranded DNA genomes that are generally associated with relatively mild, self-limiting diseases in humans. Rely on cellular systems for expression of viral information during reproduction in permissive cells and can transform normal cell in culture Structure Words to Define: Fibres : Virion protein that projects from the penton base; distal knob carriers binding sites for cellular receptors Pentons : Composed of the fibre and the penton base. The penton bases are structural units, made of proteins, at axes of 5-fold rotational symmetry; anchor fibres; bind to cell surface integrins to induce internalization of particles and penetration of endosomal membrane Hexons : major structural unit of the capsid, composed of proteins; Hexons motif consists of beta=barrel (term used to describe multiple beta-sheets); stable hollow base structure Linear, double stranded deoxyribonucleic acid (DNA) genomes Inner cavity contains DNA genome, basic core proteins, terminal proteins, and viral protease - Basic Core Proteins V-occupies external location in the core
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This note was uploaded on 04/08/2008 for the course HIST 1432 taught by Professor Kane during the Spring '08 term at Pittsburgh.

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Adenoviruses - Adenoviruses What are Adenoviruses...

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