Commercializing nano

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Unformatted text preview: resolution, tissue-specific targeting and increased retention in the blood pool. Nanomaterials also have an increasing role in tissue engineered materials and devices. For example, AngstroMedica (Newton, MA, USA) is using nanostructured materials to stabilize and regenerate bone matrix material from calcium and phosphate, and pSiMedica (The Malverns, UK) is using biodegradable silicon for bone implants. Other types of nanoscale architecture are being developed for nerve Table 3 Selected nanobiotechnology companies developing drug delivery and therapeutic applications Focus Company Therapeutics Platforma Alnis Biosciences (Emeryville, CA) Polyfunctional nanoparticles ALZA (Mountain View, CA) Lipid nanoparticles with polyethylene glycol coating; Doxil (doxorubicin liposome) on the market NanoCrystal Technologies (King of Prussia, PA) NanoMill technology for creating nanocrystals NanoMed Pharmaceuticals (Kalamazoo, MI) Nanotemplate engineering for drug and vaccine delivery systems Alnis Biosciences (Emeryville, CA) Polyfunctional nanoparticles StarPharma (Melbourne, Australia) VivaGel anti-HIV dendrimer (phase I) Advectus Life Sciences (West Vancouver, BC, Canada) NanoCure system for delivery of anticancer drugs across blood-brain barrier BioDelivery Sciences (Newark, NJ) BioOral nanocochleates cigar-shaped structures comprised of lipid bilayers BioSante Pharmaceuticals (Lincolnshire, IL) Drug delivery Nanoparticulate platform (CAP) for drug delivery (phase I) C-Sixty (Houston, TX) Fullerene-based drug delivery CytImmune Sciences (College Park, MD) Tumor necrosis factor bound to colloidal gold nanocrystals for targeting tumors; vector with docking site for gene therapy NanoCarrier (Chiba, Japan) Antimicrobial nanoemulsions (phase II) NanoSpectra Biosciences (Houston, Texas) Nanoshells for optical therapies Targesome (Palo Alto, CA) aUnless NanoCap micellar nanoparticle for water-insoluble drugs (under development) NanoBio (Ann Arbor, MI) Injectable nanospheres for therapeutic or diagnostic agents otherwise specified in parentheses, technology in preclinical development. Locations are in United States unless otherwise stated. NATURE BIOTECHNOLOGY VOLUME 21 NUMBER 10 OCTOBER 2003 1141 F E AT U R E Box 3 Nanotechnology takes on microarrays © 2003 Nature Publishing Group a b Figure 5 Nanosys nanostructured microarray. (a) Top-view scanning electron microscopy (SEM) micrograph of nanostructured array feature. (b) Side-view SEM micrograph of nanostructured array feature. Open architecture mesh wets evenly and allows analyte diffusion to binding sites. Source: Nanosys. Although massively parallel platforms such as microarrays have engendered excitement because of their unprecedented throughput, they remain hampered by problems such as reproducibility, sensitivity and poor signalto-noise ratios. Two companies are looking regeneration at NanoMateria (Chicago, IL, Fig. 3). The use of nanotechnology in implantable device...
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This document was uploaded on 09/24/2013.

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