This preview shows page 1. Sign up to view the full content.
Unformatted text preview: ently in
development at NanoPlex (Mountain View,
CA, USA) and Nanosys (Palo Alto, CA,
USA). Used as another form of molecular
tag, they can be optically scanned as literal
bar codes to differentiate molecular species.
Such systems offer advantages over conventional labeling in that there are a large number of different labels that can be
constructed, multiplexing is possible, and
the signal is long-lived.
Colloidal gold and silver are used already
in molecular detection and separation,
where their size can be reproducibly
engineered to submicron dimensions
for controlled chemical architecture and
high surface-to-volume loading capacity.
Companies working in this area, such as
Nanosphere (Chicago, IL, USA) and
Genicon Sciences (San Diego, CA, USA), are
taking advantage of the optical difference
between solution-bound nanoparticles and Table 2 Selected nanobiotechnology companies developing bioanalysis applications SPM Companies Platforma Hitachi High Technologies (London, UK) Technology Electron-beam lithography (on market) Imago Scientific Instruments (Madison, WI) Arrays Leap atom probe microscope (on market) Veeco (Woodbury, NY) Near-field scanning optical microscope (on market) Affymetrix (Santa Clara, CA) Nanoarrays ∼10,000-fold smaller than conventional arrays (on market) Nanogen (San Diego, CA) Oligonucleotide arrays with polarized features (on market) NanoInk (Chicago, IL)
Molecular tags High-density oligonucleotide (GeneChip) arrays (on market) BioForce Nanosciences (Ames, IA) Dip-pen nanolithography system (on market) Dendritic Nanotechnologies (Mt. Pleasant, MI) Dendrimers (on market) Evident Technologies (available through Ocean Semiconductor nanocrystal quantum dots (on market) Optics, Dunedin, FL, USA)
Genicon Sciences (San Diego, CA) Two-color microarray tool kit; resonance light-scattering detection and imaging instrument NanoPlex (Mountain View, CA) Gold nanoparticle probes and detection system Quantum Dot (Hayward, CA)
Microfluidics Nano-bar-codes particle kit (on market) Nanosphere (Chicago, IL) Quantum-dot conjugates (streptavidin, protein A, biotin) (on market)
Microfluidics (LabChip; on market) Fluidigm (South San Francisco, CA) Multilayer soft lithography microfluidics Nanostream (Pasadena, CA) High-throughput screening platforms Surface Logix (Brighton, MA)
aUnless Caliper Technologies (Mountain View, CA) High-throughput screening platforms using soft lithography and biosurface chemistry otherwise specified in parentheses, platform under development. Locations are in United States unless otherwise stated. NATURE BIOTECHNOLOGY VOLUME 21 NUMBER 10 OCTOBER 2003 1139 © 2003 Nature Publishing Group http://www.nature.com/naturebiotechnology F E AT U R E
aggregates formed by molecular affinity in
Drug delivery and therapeutics. Because
of their size, nanoscale assemblies offer
unique opportunities in drug delivery and in
therapeutics (Table 3). Early ‘cosmeceutical’
products have included liposomes (lipidb...
View Full Document
This document was uploaded on 09/24/2013.
- Fall '13