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Identifying the Goldilocks Model -- VanHook 6 (261)_ ec36 -- Science Signaling

Identifying the Goldilocks Model -- VanHook 6 (261)_ ec36 -- Science Signaling

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2/5/13 Identifying the Goldilocks Model -- VanHook 6 (261): ec36 -- Science Signaling stke.sciencemag.org.ezproxy.cul.columbia.edu/cgi/content/abstract/sigtrans;6/261/ec36?view=abstract 1/2 Home > Science Signaling > Literature > Editors' Choice > VanHook, p. ec36 Sci. Signal. , 5 February 2013 Vol. 6 , Issue 261, p. ec36 [DOI: 10.1126/scisignal.2004025] EDITORS' CHOICE Computational Biology Identifying the Goldilocks Model Annalisa M. VanHook Science Signaling , AAAS, Washington, DC 20005, USA The quantitative transcriptional responses to activation of signaling pathways depend on many factors, including chromatin structure, the presence or absence of transcription factors, the magnitude and duration of the signal, and combinatorial inputs from multiple pathways. Neuert et al . used the high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathway of the budding yeast Saccharomyces cerevisiae to build models to predict the dynamics of the transcriptional response to osmotic stress. When cells experience osmotic shock, the kinase Hog1 translocates into the nucleus, where it activates expression of osmosensitive genes. Nuclear translocation of Hog1 was similar in all cells, but the magnitude of the transcriptional response differed between cells. Using single-molecule fluorescence in situ hybridization (smFISH) to quantify
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Identifying the Goldilocks Model -- VanHook 6 (261)_ ec36 -- Science Signaling

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