Unformatted text preview: ancient times because of its excellent hepatoprotective action. Pichrorriza kurroa Royle contains kutokoside and picroliv which are potential hepatoprotectant.6‐9 Phyllanthus amarus is another most important plant selected for clinical trials.The present paper describes literature survey on liver protective herbal drugs; herbal drugs used as a hepatoprotective in Ayurvedic system of medicine. From hundreds of year, the Ayurvedic formulations are being employed in Indian subcontinent to cure liver disorders, natural chemical constituents and inorganic salts are prescribed to treat the liver complications of minor to sevior type of liver toxicity. Liver protective herbal drugs contains a variety of chemical constituents like phenols, coumarins, lignans, essential oil, monoterpenes, carotinoids, glycosides, flavonoids, lipids, alkaloids and xanthines. Sesquiterpenes have been reported from Atracyclodes maerocephala. Andrographis panicles and Gardenial florida are the only source of diterpenes and carotinoids respectively. Extract of about 25 different plants have been reported to cure liver disorders. Some herbal drugs such as like Adenosma indiana, aromatic amides of Clausena lansium, Ginseng saponins and polysaccharides of Auricularia auricular and Tremella fuciform also possess hepatoprotective property (Table 1). In Ayurveda about 77 herbal drugs are used as hepatoprotective agents. There are different plants and their parts used for liver treatment, such as Sanguinaria candesis (roots), grown in U.S.A. and Canada is advised in hepatic enlargement and in the hysteric without any organic lesion. Tarazacum officinale roots, found in Europe, Himalaya, Nigeria, North‐West Provinces and North America, are advised in chronic liver infection.10 Chelidonium majus whole plant of Europe and North America is given in both acute and chronic hepatitis. When the patient suffers from gout in addition to hepatitis, Colchicum is useful. Linseed alone or with opium is used as poultices over the hepatic region in acute hepatitis. Hydastis is useful in malarial jaundice and that due to catarrh of the bile ducts. Podophyllin is useful in catarrhal or malarial jaundice when stool are clay colored and exhibit no trace of bile; stillinea is used to relieve torpid liver following intermittent fever had to cure jaundice. Bryonia alba root, a perennial plant of southern Europe and East Indies, is useful in various hepatic diseases chiefly hepatalgia. (Table 2). Various drug formulations are employed in Ayurvedic system of medicine. The most widely used formulations are: Jawarish amla, Jawarish al tursh, Jawarish alsirin, Jawarish mastagi, Dawae
jigarpith, DawaeKarim, Salajin bajuru and Sharbat bajuri. Most of these formulations contain Andrographis paniculata Nees, Asteracatha longifolia Nees, Boerrhaavia diffusa Linn, Cinchorium intybus Linn, Eclipta alba Hassk, Oldenlandia corymbasa Linn., Picrorrhiza kurroa, Rolex benth, Solanum nigrum Linn., Terminalia chebula...
View Full Document
- Fall '11
- Pharmacology, Linn, Pharm Clin Res, Suralkar, J Pharm Clin Res, Livokin, Fumaria officinalis Linn