Patient lacking a functional gene and the missing or

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Unformatted text preview: e replaced. The cells can be grown for a while in culture and then replaced into the patient. An alternative approach is to place the missing gene into a viral vector and then “infect’’ the patient with the virus in the hope that the missing gene will then be expressed in the patient’s cells. Drug Screening and Development Cell-based assays have become increasingly important for the pharmaceutical industry, not just for cytotoxicity testing but also for high throughput screening of compounds that may have potential use as drugs. Originally, these cell culture tests were done in 96 well plates, but increasing use is now being made of 384 and 1536 well plates. 7 References 1. Culture of Animal Cells, A Manual of Basic Technique (1994) R. Ian Freshney, 3rd edition, Alan R. Liss, Inc., New York. 2. Methods in Enzymology: Cell Culture, Vol. 58, (1979) W. B. Jacoby and I. H. Pasten, eds. Academic Press, New York. 3. Cell and Tissue Culture (1975) John Paul, 5th edition, Churchill Livingstone, Edinburgh. 4. Animal Cell Culture Methods, Volume 57, (1998) J. Mather and D. Barnes, eds. Methods in Cell Biology, Academic Press, San Diego, 1998. 5. Growth, Nutrition and Metabolism of Cells in Culture (1972) G. H. Rothblat and V. J. Cristofalo eds. Volumes 1-3 by Academic Press, New York. 6. Osmolality of Mammalian Blood and of Media for Culture of Mammalian Cells, (1970). C. Waymouth, In Vitro, Volume 6: 109-127. 7. Understanding and Managing Cell Culture Contamination Corning Life Sciences Technical Bulletin. This is available on the Corning Life Sciences web site at www.corning.com/lifesciences. 8. General Guide for Identifying and Correcting Common Cell Culture Growth and Attachment Problems Corning Life Sciences Technical Bulletin. This is available on the Corning Life Sciences web site at www.corning.com/ lifesciences. 9. General Guide for Cryogenically Storing Animal Cell Cultures Corning Life Sciences Technical Bulletin. This is available on the Corning Life Sciences web site at www.corning.com/lifesciences. 10. Endotoxins and Cell Culture Corning Life Sciences Technical Bulletin. This is available on the Corning Life Sciences web site at www.corning.com/lifesciences. www.corning.com/lifesciences A S I A / PA C I F I C Australia t 61 2-9416-0492 f 61 2-9416-0493 China t 86 21-3222-4666 f 86 21-6288-1575 Hong Kong t 852-2807-2723 f 852-2807-2152 India t 91-124-235 7850 f 91-124-401 0207 Japan t 81 (0) 3-3586 1996/1997 f 81 (0) 3-3586 1291/1292 Korea t 82 2-796-9500 f 82 2-796-9300 Singapore t 65 6733-6511 f 65 6861-2913 Taiwan t 886 2-2716-0338 f 886 2-2716-0339 EUROPE France t 0800 916 882 f 0800 918 636 Germany t 0800 101 1153 f 0800 101 2427 The Netherlands t 31 20 655 79 28 f 31 20 659 76 73 Corning, CellCube, CellSTACK, and Transwell are registered trademarks of Corning Incorporated, Corning, NY. Snapwell and Netwell are trademarks of Corning Incorporated, Corning, NY. Corning Incorporated, One Riverfront Plaza, Corning, New York 14831-0001 United Kingdom t 0800 376 8660 f 0800 279 1117 All Other European Countries t 31 (0) 20 659 60 51 f 31 (0) 20 659 76 73 L AT I N A M E R I C A Brasil t (55-11) 3089-7419 f (55-11) 3167-0700 Mexico t (52-81) 8158-8400 f (52-81) 8313-8589 Printed in USA 3/08 POD Tower 2, 4th Floor 900 Chelmsford St. Lowell, MA 01851 t 800.492.1110 t 978.442.2200 f 978.442.2476 Worldwide Support Offices © 2008 Corning Incorporated Corning Incorporated Life Sciences CLS-AN-042-REV1 For additional product or technical information, please visit www.corning.com/ lifesciences or call 1.800.492.1110. Outside the United States, please call +1.978.442.2200 or contact your local Corning sales office listed below....
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