That cause the change can be studied cultured cancer

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Unformatted text preview: serve as a test system to determine suitable drugs and methods for selectively destroying types of cancer. Virology One of the earliest and major uses of cell culture is the replication of viruses in cell cultures (in place of animals) for use in vaccine production. Cell cultures are also widely used in the clinical detection and isolation of viruses, as well as basic research into how they grow and infect organisms. Cell-Based Manufacturing Corning® roller bottles are widely used for producing viral vaccines. The Corning CellCube® bioreactor system is ideal for mass production of anchorage-dependent cells. While cultured cells can be used to produce many important products, three areas are generating the most interest. The first is the large-scale production of viruses for use in vaccine production. These include vaccines for polio, rabies, chicken pox, hepatitis B and measles. Second, is the large-scale production of cells that have been genetically engineered to produce proteins that have medicinal or commercial value. These include monoclonal antibodies, insulin, hormones, etc. Third, is the use of cells as replacement tissues and organs. Artificial skin for use in treating burns and ulcers is the first commercially available product. However, testing is underway on artificial organs such as pancreas, liver and kidney. A potential supply of replacement cells and tissues may come out of work currently being done with both embryonic and adult stem cells. These are cells that have the potential to differentiate into a variety of different cell types. It is hoped that learning how to control the development of these cells may offer new treatment approaches for a wide variety of medical conditions. Genetic Counseling Amniocentesis, a diagnostic technique that enables doctors to remove and culture fetal cells from pregnant women, has given doctors an important tool for the early diagnosis of fetal disorders. These cells can then be examined for abnormalities in their chromosomes and genes using karyotyping, chromosome painting and other molecular techniques. Genetic Engineering The ability to transfect or reprogram cultured cells with new genetic material (DNA and genes) has provided a major tool to molecular biologists wishing to study the cellular effects of the expression of theses genes (new proteins). These techniques can also be used to produce these new proteins in large quantity in cultured cells for further study. Insect cells are widely used as miniature cells factories to express substantial quantities of proteins that they manufacture after being infected with genetically engineered baculoviruses. Corning® Erlenmeyer flasks are often used for growing insect cells in suspension. 7 Corning microplates are widely used for drug screening. Gene Therapy The ability to genetically engineer cells has also led to their use for gene therapy. Cells can be removed from a patient lacking a functional gene and the missing or damaged gene can then b...
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