Bio 321 F13 lecture 8 v2

Allozyme locus 43 subpopulagons fst 038

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Unformatted text preview: 2(0.83x0.17) + 2(0.91x0.09)]/43 =0.0220 = expected proportion of heterozygotes within subpopulations assuming random mating, averaged over all subpopulations Levin (1978), Pgm-1 locus (2 alleles) 43 Texas subpopulations of Phlox cuspidata 40 fixed for the b allele (p=1) 3 were variable subpopulation pi Hi 1-40 1 0 41 0.49 0.17 42 0.83 0.06 43 0.91 0.06 p = [(40x1)+0.49+0.83+0.91]/43 = 0.9821 q = 1-p = 0.0179 HT = 2pq = 0.0352 =expected proportion of heterozygotes over the entire metapopulation Levin (1978), Pgm-1 locus (2 alleles) 43 Texas subpopulations of Phlox cuspidata 40 fixed for the b allele (p=1) 3 were variable subpopulation pi Hi 1-40 1 0 41 0.49 0.17 42 0.83 0.06 43 0.91 0.06 FIS =(HS-HI)/HS = (0.0220-0.0067)/0.0220 = 0.70 FST = (HT-HS)/HT = (0.0352-0.0220)/0.0352 = 0.38 FIT = (HT-HI)/HT = (0.0352-0.0067)/0.0352 = 0.81 check using (1-FIS)(1-FST) = (1-FIT) (1-0.7)(1-0.28) = (1-0.81) => 0.19 = 0.19 interpreGng the result •  FIS very large = high level of inbreeding –  (these are self- ferGlizing plants; although they don’t always self ferGlize) –  comes from 3 unfixed populaGons –  populaGons with no geneGc variaGon do not contribute to the esGmate •  there is no heterozygosity to reduce •  FST also very large = also likely due to high degree of self ferGlizaGon what about data with mulGple...? •  mulGple alleles = method exists –  we won’t worry about that here •  mulGple loci –  can average all of the individual FST values from each locus –  more appropriate = average HS and HT over loci http://www.library.auckland.ac.nz/subjects/ bio/pdfs/733Pop-g-stats2.pdf...
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This note was uploaded on 10/01/2013 for the course BIO 321 taught by Professor John during the Spring '12 term at SUNY Stony Brook.

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