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BIO3320 Introduction 082613 JKim - Lecture 1 Introduc.on...

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Lecture’1.’Introduc±on’ Aug’26’2013’ Required’reading’ Review’ar±cle’posted’in’eLearning’ Hallmarks of Cancer Jung-whan (Jay) Kim, D.V.M., Ph.D.
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Kate O’Donnell
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Quiz starts at exactly 11:35 am If you are late, you will have less ;me for your quiz. One homework will be given before the Exam 1 - Exam 1 and 2 will have the same format of the homework Exams’and’Quizzes’ Which’of’following’is’true’?’ (point +1, 0, -1) a. UTD’is’located’in’Houston’ b.’Jay’Kim’is’a’veterinarian’ c.’Jay’Kim’lab’focuses’on’cancer’ d. b’and’c’ e. a,’b’and’c’ True’or’False’ (point +1, 0, -2) The’official’mascot’of’UT’Dallas’is’ Blaze False How’many’±mes’do’you’breath’per’minute? (Point 5)
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University’of’Texas’at’Dallas’ ’-’Assistant’Professor Hypoxia’ Tumor’Microenvironment’ Tumor’Metabolism’ Animal’Model’ Cancer’Biology’
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Cancer Cancer’is’a’group’of’gene.c’diseases’in’which’abnormal’cells’divide’without’control’and’are’able’to’invade’other’.ssues±’ Mechanisms’that’maintain’normal’growth’rates’malfunc.on’to’cause’excess,’uncontrolled’cell’division±’ ’-’Oncogenes:’excessively’ac.ve’in’growth’or’prolifera.on’promo.on’ ’-’Tumor’suppressor’genes:’muta.ons’that’inac.vate’them’allow’uncontrolled’prolifera.on’ “Car with stuck gas pedals and broken brakes”
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O 2 hypoxic necro.c Hypoxia’(Low’oxygen’tension) Hypoxia’occurs’in’cancer,’.ssue’injury,’inflamma.on’and’obesity±’ Rapidly’growing’solid’tumor’outgrows’its’blood’supply±’ Strong’angiogenic’signals’from’cancer’cells’promotes’new’blood’vessel’forma.on±’ Tumor’blood’vessels’are’structurally’and’func.onally’abnormal±’ - Vicious cycle - HIF-1
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HIF-1’is’a’master’transcrip.on’factor’of’oxygen’homeostasis±’ Prolyl’hydroxylase’(PHD)’uses’O 2 ’as’a’substrate’to’ hydroxylate’HIF-1α±’ Hydroxylated’HIF-1α’is’bound’by’von’ Hippel-Lindau’(VHL)’that’targets’HIF-1α’for’ proteasomal’degrada.on±’ O 2 O 2 O 2 G. Semenza, Nat Rev Cancers 2003 Hypoxia-inducible’factor’-1’(HIF-1)
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