Lobular carcinoma in situ 20mm diameter intraductal

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Unformatted text preview: P ROS pyruvate lactate PDK H2O NADH, FADH2 O2 PDH acetyl- CoA TCA cycle J. Kim et. al. Cell Metabolism, 2006 J. Kim et. al. Mol. Cell. Biol. 2007 J. Kim et. al. Mol. Cell. Biol. 2004 R. Fukuda et. al. Cell, 2007 Exploring novel PDK func.ons Iden;fying novel proteins that interact with PDK HIF- 1 glucose Glycolysis ??? ATP Suppression of mitochondrial func.on ATP ROS pyruvate ??? lactate PDK H2O NADH, FADH2 PDH ??? acetyl- CoA TCA cycle O2 Why don’t we get more cancer? In 110 autopsies of young and middle-aged women (range 20-54), malignancy was found in 22 women (20%) of which only one was known to have had clinical invasive breast cancer. Lobular carcinoma in situ, 2.0mm diameter Intraductal carcinoma, 2.4mm diameter M. Nielsen et. al. Br. J. Cancer, 1987 M. Bissell & W. Hines, Nature Medicine, 2011 Tumor microenvironment Solid tumor comprises tumor cells and various hos...
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This note was uploaded on 10/02/2013 for the course BIOL 3302 taught by Professor Candas during the Fall '10 term at University of Texas at Dallas, Richardson.

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