BIO3320 Introduction 082613 JKim

Ons of pyruvate dehydrogenase kinase pdk in hypoxia

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Unformatted text preview: IF- 1 and HIF- 2 Tissue injuries including fibrosis and wound cause hypoxia and HIF activation. Fibroblast is the major cell type involved in the fibrotic and wound healing processes. Investigating roles for fibroblast HIF signaling in fibrosis and wound healing Normal lung ??? ??? Extracellular Matrix Collagen Fibronec.n Myofibroblast Fibrosis Idiopathic Pulmonary Fibrosis ??? ??? Pulmonary fibrosis Bleomycin Injection (3 wk) H & E Trichrome Wound healing R. Clark et al. J of Invest Derm. 2007 Wound healing Summary the mechanisms how HIFs affect tumorigenic process, the tumor microenvironment and chemotherapeu.c sensi.vity - Tumor cells vs stromal cells (fibroblasts and adipocytes) - Breast cancer, lung cancer and pancrea.c cancer - Various transgenic and condi.on knock- out mouse models Studying the molecular link between obesity and cancer - interac.on between tumor cells and adipocytes - systemic effec...
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