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Unformatted text preview: y cannot
signal to a mating partner; others are sterile because they
cannot respond to a signal. A simple test enables one to distinguish between the two. Both a and mating pheromones
elicit an arrest of cell division in the receptive cell type. If
one places a patch of cells of one mating type on a patch of
cells of the opposite mating type, a zone of growth inhibition
appears where the pheromone from one cell type has caused
the arrest of division of the other cell type. Sterile mutants
that produce no zone of growth inhibition either fail to secrete mating pheromone or they secrete mating pheromone
but are unresponsive to pheromone from the opposite cell
type (Fig. A.14). Cells Respond to the Binding
of Pheromone Through a Signal
By analyzing mutants that are sterile but still synthesize
pheromone, yeast researchers identiﬁed many components
of the signal transduction systems through which cells
respond to the binding of pheromone at their surface.
Plasma membrane receptors at the cell surface mediate the
pheromone response. a cells produce -phe...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.
- Spring '08