Saccharomyces_A

Chemical signals pheromones released by a and cells

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Unformatted text preview: required for mating Transcription of genes required for mating α cell a cell Figure A.13 Pheromones bind to receptors and activate a signal transduction pathway. Chemical signals (pheromones) released by a and cells bind to receptors on the cell surface of cells of the opposite mating type. Once bound to the receptor, a signal is sent to the nucleus via a signal transduction pathway and transcription of genes required for mating is turned on. Signal Transduction Pathway Involves G Proteins and a Protein Kinase Cascade a cells and cells communicate with each other for the purpose of mating through extracellular segments of the receptors that interact directly with the appropriate mating pheromone. Receptor segments exposed to the inside of the cell are coupled to a membrane-bound G protein composed of , , and subunits, encoded respectively by the SCG1, STE4, and STE18 genes. The mating pheromones, receptors, and G proteins act in concert as a molecular switch, with the binding of pheromone...
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