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Unformatted text preview: es. Eventually the minimal ploidy needed
for survival was reduced to the haploid state. The genome
was left, however, with the remnants of the ancient duplications and still retains many duplicated genes scattered
around the genome. Figure A.6 shows a map of the yeast
genome with 53 pairs of otherwise nonhomologous chromosomal segments identiﬁed as having been originally 5 derived by duplication. Yeast geneticists estimate that about
15% of all yeast proteins are encoded by duplicated, unlinked genes. Examples of duplicated genes include gene
pairs that code for transcription factors, translation factors,
protein kinases, contractile proteins like myosin and tubulin, the cyclins, the histones, and the mating pheromones. Tools of the Yeast Geneticist
Yeast is a powerful system for classical mutant isolation
and characterization as well as systematic whole genome
analyses using genome data and microarrays. Several techniques of yeast genetics enable researchers to answer questions that are difﬁcult, if not impossible, to resolve in other
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.
- Spring '08