Saccharomyces_A

Large numbers of cells can easily be grown and

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Unformatted text preview: rved from yeast to humans. • Large numbers of cells can easily be grown and assayed. • Mutations can be isolated in diploids, then analyzed in haploids. • Conditional mutants can be isolated. • Recombination frequencies are high, facilitating molecular manipulations. • Genome size is small and the number of genes is low, so analyses and manipulations of the whole genome are possible. A.2 Cell Differentiation in Yeast: Mechanisms for Determining Cell Type Like the specialized liver, muscle, and nerve cells of animals, the a, , and a / cells of yeast are differentiated cells that express different sets of genes. The three cell types in yeast differ in how they respond to signals from the environment and in their developmental potential. Three different genetic programs establish the differentiation pathways leading to each cell type. Because the establishment of cell identity is basic to the differentiation and development of multicellular organisms, our understanding of the process in yeast serves as a model for de...
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