Second the number of genes directly regulated by

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Unformatted text preview: and all signaling for mating appears to flow through Ste12, yet pheromone treatment causes the repression of many genes involved in cell-cycle progression, DNA replication, budding, and mitosis. Second, the number of genes directly regulated by Ste12 is much smaller than the number of genes whose expression is altered by pheromone treatment. These findings suggest the existence of negative regulators that function downstream of Ste12 in the pheromone response circuitry. As this discussion shows, genomic analysis using DNA arrays will bring us closer to a complete molecular picture of the sequence of developmental events that lead to mating following exposure to pheromone. har06584_refA_001-020 16 11/4/06 10:10 AM Page 16 Reference A Saccharomyces cerevisiae: Genetic Portrait of a Yeast Connections Because it is relatively easy to find and analyze mutant yeast cells, as well as to replace yeast genes with engineered variants, yeast has become the model organism for studying eukaryotic cell biology. Three different genetic programs, each governing...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.

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