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Unformatted text preview: and all signaling for mating appears to ﬂow
through Ste12, yet pheromone treatment causes the repression of many genes involved in cell-cycle progression,
DNA replication, budding, and mitosis. Second, the number of genes directly regulated by Ste12 is much smaller
than the number of genes whose expression is altered by
pheromone treatment. These ﬁndings suggest the existence
of negative regulators that function downstream of Ste12 in
the pheromone response circuitry.
As this discussion shows, genomic analysis using
DNA arrays will bring us closer to a complete molecular
picture of the sequence of developmental events that lead
to mating following exposure to pheromone. har06584_refA_001-020 16 11/4/06 10:10 AM Page 16 Reference A Saccharomyces cerevisiae: Genetic Portrait of a Yeast Connections
Because it is relatively easy to ﬁnd and analyze mutant
yeast cells, as well as to replace yeast genes with engineered variants, yeast has become the model organism for
studying eukaryotic cell biology. Three different genetic
programs, each governing...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.
- Spring '08